Modification of antidote therapy for poisoning due to massive admission of paracetamol

Background. Paracetamol poisoning is common all over the world, including in Russia. In 20–25% of cases, a massive dose drug observed: more than 30–40 g paracetamol at time.The aim study was to demonstrate efficacy using an increased doses acetylcysteine treatment admission.Results. Patient G., 22 years old, took 70 tablets (35 g) for suicide 3 hours before admission hospital. The blood level 4 after taking it 694.94 µg/mL. Upon hospital, administering started according 12-hour scheme. Subsequently, administration continued 20-hour regimen with dosage 2nd stage. Laboratory parameters, aspartate aminotransferase and alanine aminotransferase, remained within reference values during hospital stay. Conclusion. case report we have presented shows expediency paracetamol, which contributes prevention development severe complications favorable course outcome disease.